Five years after their dangerous journey across the United States following a pandemic, Ellie and Joel have settled in Jackson, Wyoming. By living in a thriving community of survivors, they have gained peace and stability despite the constant threat from the infected and other more desperate survivors.

As a violent event disrupts the peace, Ellie embarks on a relentless journey to seek revenge and an end. As she chases those responsible one by one, she is confronted with the devastating physical and emotional consequences of her actions.