DNA: Dark Native Apostle is a single player science fiction themed action puzzle game in which you take control of B13, a human who is genetically modified. The game starts with the player trying to escape the testing facility in which he is held.

Gameplay includes fighting off enemies by placing bombs on the floor that will explode with a slide delay. During play the player can find Bio chips that can increase speed and power of the bombs. Puzzle include finding objects and inserting them so you can move on, finding switches that open doors or moving crates to reach certain areas. Aside from the normal enemies there are also bosses. HP can be recovered by picking up health or regenerating it at a save points.