En mystisk ny fiende börjar terrorisera Gongmen City och det är upp till Po och Furious Five (De Fruktade Fem) att besegra hotet och återställa lugnet.

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Kung Fu Panda 2 will allow players to command Po using the stylus and unleash awesome kung fu moves against enemies alongside his friends and fellow kung fu masters, the Furious Five: Tigress, Monkey, Crane, Viper and Mantis. In addition, the Nintendo DS version offers an addictive card game called Five-Card Fu, which can be played either alone or with a friend. The game is played on a 3x3 grid which contains nine squares. To get started, the player must select five cards from their in-game library and place one card in one of the nine squares. Each card will have a number ranging from one through nine on each side of the card. In order to win, the player must strategize on which square they will occupy first as well as which card to use. Once the player places a card in a square, the opponent will have to place a card on an adjacent square that beats the numerical value of the card the first player placed. The player that occupies the grid with the highest numerical value wins.