Letters from Whitechapel is a thematically engrossing board game of deduction and bluffing in which one player takes the role of the infamous Jack the Ripper, while up to five other players are detectives working together to pursue him through Victorian London. After committing his horrible murders, Jack must outmaneuver the detectives in the tangled streets of the Whitechapel District. Meanwhile, the detectives must use clever deduction and their superior numbers to hunt Jack the Ripper down before he can kill again or elude them forever.

Played over four rounds, Letters from Whitechapel is an engaging game of cat-and-mouse. Each round, the player controlling Jack selects a victim, commits a grisly murder, then attempts to escape to his secret hideout before being apprehended by any of five pursuing investigators. As for the investigators themselves, they must watch and wait, springing to action when Jack strikes, then working together to narrow down his true location and make an arrest.