In Xyanide: Resurrection, you play as Drake. On your last mission, you had to take the evil witch Aguira to the place where she would be executed. However, this did not go according to plan and Aguira, who has destroyed entire planets and civilizations, escapes. You are now in a strange world where the laws of physics do not apply. You are in a world that Aguira creates with the help of the powerful Xyanide in her head.

Therefore, step into your spaceship and fly around in a world created by your greatest enemy. Everything you encounter is hostile and only with quick reflexes can you avoid the waves of enemies. Evading is not enough, you will also have to shoot your enemies. Namely, a destroyed enemy leaves Xyanide behind and you will have to collect it to escape the world of Aguira.